Artificial Intelligence startups in Southern California
The region's largest single cluster by company count — AI and machine learning threaded through nearly every other industry here, from defense to biotech to entertainment.
Companies
Building the definitive all-in-one on-device AI productivity tool
AI powered ERP for Construction
The first platform where families can create AI cartoons in minutes
Industrial Controllers built for AI
Force-sensing wristband for training robotic AI
The Creative OS for AI video
Anchr provides AI agents for physical operations in industries such as food distribution, industrial and MRO, healthcare and pharma, building and technical supplies, and consumer packaged goods.
Synergetics.AI offers a trusted agentic infrastructure platform that allows AI agents to identify, communicate, and transact securely across enterprise boundaries.
PADO offers AI orchestration solutions for data centers that optimize power usage, cut operational costs, and ensure scalable performance for mission-critical workloads.
Subsense is building the first NanoBCI, a non-surgical, nanoparticle-based Brain-Computer Interface platform designed to transform the treatment of neurological disorders by uniting the human brain, technology, and AI.
Nectir AI provides personalized, FERPA-safe AI Assistants that are built directly from course content and integrated into Learning Management Systems (LMS) for higher education.
Hardline is an AI voice tool for construction that automatically summarizes phone calls and site walks to write daily logs, extract tasks, and flag urgent items.
Kopacetic AI provides empathic AI-powered communication coaching.
Luxury Presence provides a growth platform for real estate professionals, offering services like real estate websites, SEO, social media management, paid ads management, and an AI CRM.
Roadrunner AI provides a workspace for the search, analysis, and synthesis of scientific literature, purpose-built for the rigor and methods of life sciences, healthcare, and biomedical research.