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Software & SaaS startups in Southern California

Software companies across the region, from Irvine's enterprise SaaS bench to Santa Monica's consumer apps: the broadest category here after AI, and the one people search for by city.

409
companies
$24.89B
total raised
46
cities

Companies

Influsence, Inc. hero photo
$5K
Influsence, Inc.
San Diego, CA · Founded 2023

Influsence, Inc. provides an AI SaaS platform that offers data insights for influencer marketing to help increase reach, engagement, and revenue for ad agencies and companies.

B2B
Clarity Management Aggregator, LLC hero photo
$44
Clarity Management Aggregator, LLC
Los Angeles, CA · Founded 2025

Clarity AI is an AI-native platform for extra-financial intelligence that supports financial institutions, companies, governments, and consumers in making decisions.

Industrials
chrt
Los Angeles, CA · Founded 2025 · 5 employees

chrt is a logistics platform for time-critical shipping

Y CombinatorB2B
Axle Health
Los Angeles, CA · Founded 2021 · 14 employees

Scheduling and workforce management SaaS for home healthcare providers

Y CombinatorHealthcare
Plura (formerly Bloom Community)
San Diego, CA · Founded 2020 · 5 employees

The social app for edge-of-culture communities

Y CombinatorConsumer
Bootstrapped
KanDo
Irvine, CA · 2 employees

KanDo is an AI-powered knowledge and process management tool for creating and managing AI-assisted Standard Operating Procedures, with enterprise-grade multi-tenant authentication and an intelligent knowledge base.

BootstrappedEnterprise Software
Bootstrapped
JouraBooks
Irvine, CA · 1 employees

JouraBooks is desktop-native accounting software for teams migrating off QuickBooks Desktop, offering a practical QBD import path, local-first data control on your own machine, and an AI assistant (Ask Joura) for accounting and back-office work. Currently in private beta.

BootstrappedSoftware as a service (SaaS)
Bootstrapped
NavOps
Los Angeles, CA · ~1-10 employees

NavOps connects the software your business already uses and uses AI to automate repetitive work across those systems.

BootstrappedArtificial Intelligence (AI)
Illuminate Education
Irvine, CA · Founded 2009 · 751 employees
Software as a service (SaaS)
Kable
Santa Monica, CA · Founded 2021

Usage-based billing for API companies

Billing
GOAT Group
Los Angeles, CA · Founded 2012 · 1600 employees

Platform for the greatest products from the past, present and future.

Y CombinatorConsumer
Argo
Los Angeles, CA · Founded 2022 · 10 employees

A social streaming platform powered by creators and fans

Y CombinatorConsumer
Applied Data Finance hero photo
Applied Data Finance
San Diego, CA

Applied Data Finance is a fintech innovator that offers fair and responsible credit access to underestimated U.S. consumers through an AI-powered underwriting and lending platform.

Fintech
Condor Software hero photo
Condor Software
San Diego, CA

Condor is an AI-powered platform that unifies clinical, operational, and financial data into a single source of truth for life sciences companies to manage R&D finances.

B2B
SFOX hero photo
SFOX
Los Angeles, CA · Founded 2014 · 60 employees

Crypto-currency trading platform.

Y CombinatorFintech
HONK hero photo
HONK
Los Angeles, CA

HONK provides an AI-powered platform for roadside assistance, specialized vehicle services, accident management, vehicle logistics, and catastrophe event management.

B2B
InHouse hero photo
InHouse
Los Angeles, CA

InHouse offers a platform to design rooms by trying on furniture in a digital twin of one's home and allows users to explore ideas, layouts, and purchase pieces.

Consumer
Talino Venture Labs hero photo
Talino Venture Labs
Los Angeles, CA

Talino Fintech Foundry helps companies build and scale global financial products faster, more securely, and at lower cost by removing regulatory friction, enabling interoperability, and modernizing traditional finance with compliant stablecoin infrastructure on a unified platform.

B2B
Ember LifeSciences
Los Angeles, CA

Ember LifeSciences applies proprietary heating and cooling technology to the healthcare industry, offering self-refrigerated, cloud-based shipping boxes called Ember Cubes.

B2B
K2 Space hero photo
K2 Space
Torrance, CA

K2 Space builds high-power satellite platforms, specifically Mega Class satellites, that deliver significant power to payloads, mass on orbit, and resilience across various orbital environments.

Defense Technology
The Adversarial Company hero photo
The Adversarial Company
North Hollywood, CA

The Adversarial Company builds AI-native denial and deception systems, including WRAITH, AI software for generating and evaluating camouflage for machine-observed environments.

Defense Technology
Macro Biologics hero photo
Macro Biologics
Carlsbad, CA

Macro Biologics designs, patents, and produces advanced biomaterials for healthcare, food and water applications, and packaging.

Healthcare
Zeitview hero photo
Zeitview
Los Angeles, CA · Founded 2014 · 200 employees

Inspection software for renewable energy & sustainable infrastructure

Y CombinatorIndustrials
RocketLit
Los Angeles, CA · Founded 2016 · 11 employees

RocketLit is an adaptive learning and assessment platform.

Y CombinatorEducation
Rethoric hero photo
Rethoric
San Diego, CA · Founded 2021 · 4 employees

LinkedIn content consultancy and scheduling platform for busy founders

Y CombinatorB2B
Curri
Los Angeles, CA · Founded 2019 · 104 employees

Construction & industrial logistics platform.

Y CombinatorReal Estate and Construction
Paragon hero photo
Paragon
Los Angeles, CA · Founded 2020 · 2 employees

The embedded integration platform for SaaS apps.

Y CombinatorB2B
Epsilon3 hero photo
Epsilon3
Los Angeles, CA · Founded 2021 · 12 employees

AI-Powered ERP, MES, and Test Software for Complex Operations

Y CombinatorB2B
Cisterna Biologics
San Diego, CA · Founded 2022 · 2 employees

High quality mRNA for therapeutic application

Y CombinatorHealthcare
Pirros hero photo
Pirros
Los Angeles, CA · Founded 2022 · 44 employees

AI Platform for Architects and Engineers

Y CombinatorB2B
Whatnot
Los Angeles, CA · Founded 2020 · 731 employees

Whatnot is the largest livestream shopping platform in the U.S.

Y CombinatorConsumer
Stipop
Los Angeles, CA · Founded 2021 · 8 employees

Monetization platform for character creators

Y CombinatorConsumer
Wardstone hero photo
Wardstone
Los Angeles, CA · Founded 2025 · 8 employees

The Modular Interceptor Platform

Y CombinatorIndustrials
Sapling.ai hero photo
Sapling.ai
Los Angeles, CA · Founded 2018 · 2 employees

Language models for enterprise applications.

Y CombinatorB2B
MarqVision hero photo
MarqVision
Los Angeles, CA · Founded 2021 · 200 employees

IP operating software for brands and content companies

Y CombinatorB2B
Yummy
Los Angeles, CA · Founded 2021 · 260 employees

The everything app for LATAM

Y CombinatorConsumer
Plai hero photo
Plai
Los Angeles, CA · Founded 2021 · 20 employees

Create, launch, and optimize Facebook ads and ads on 10+ platforms

Y CombinatorB2B
Float Health
Carlsbad, CA · Founded 2022 · 3 employees

Float is the full-stack platform for Specialty Pharma

Y CombinatorHealthcare
Massdriver hero photo
Massdriver
Los Angeles, CA · Founded 2022 · 4 employees

Deploy secure, scalable cloud infrastructure in minutes not days

Y CombinatorB2B
Scanbase hero photo
Scanbase
Los Angeles, CA · Founded 2022 · 10 employees

The API for Diagnostic Test Analysis (COVID-19, FLU, RSV, STD,…

Y CombinatorHealthcare
Voker
Los Angeles, CA · Founded 2024 · 6 employees

The Agent Analytics Platform

Y CombinatorB2B
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Pixley AI
Los Angeles, CA · Founded 2025 · 2 employees

The first platform where families can create AI cartoons in minutes

Y CombinatorConsumer
ZeroSettle hero photo
ZeroSettle
San Diego, CA · Founded 2026 · 2 employees

Drop-in Direct Billing SDK for In-App Purchases

Y CombinatorFintech
Synergetics.AI
Irvine, CA

Synergetics.AI offers a trusted agentic infrastructure platform that allows AI agents to identify, communicate, and transact securely across enterprise boundaries.

B2B
Northwood Space
Torrance, CA

Northwood Space is building a global ground network for space communications by providing hardware that deploys in hours, software that orchestrates contacts, and a network that moves data from spacecraft to customer.

Defense Technology
Subsense hero photo
Subsense
Covina, CA

Subsense is building the first NanoBCI, a non-surgical, nanoparticle-based Brain-Computer Interface platform designed to transform the treatment of neurological disorders by uniting the human brain, technology, and AI.

Healthcare
Luxury Presence hero photo
Luxury Presence
Santa Monica, CA

Luxury Presence provides a growth platform for real estate professionals, offering services like real estate websites, SEO, social media management, paid ads management, and an AI CRM.

B2B
Like Lightning OKC LLC
Palm Springs, CA · Founded 2026

Lightning Communications offers nationwide cloud-based VoIP and unified communications solutions for businesses, with U.S. support and near-zero downtime

B2B
Flowly
Los Angeles, CA · Founded 2021 · 3 employees

Our mobile app reduces chronic pain for 100 million Americans.

Y CombinatorHealthcare