Medical Technology startups in Southern California

Yatiri Bio, Inc. is re-enisioning the pharmaceutical industry's current drug discovery process by integrating patient data sets with testable empirical models to guide patient selection and clinical development, utilizing advanced proteomics and bioinformatics tools and deep learning models.

BRT Biotechnologies provides high-quality macrocycle libraries using its proprietary BRiTeCycle® platform to advance drug discovery and enable rapid identification of promising drug leads for treating hard-to-drug targets.

Using Clinical Insights to Guide Patient Traffic Flow — DEPTH™ accelerates care velocity across the patient journey through Augmented Surveillance Intelligence.

Shreenika Pioneering Inc. creates high-performance, cost-effective chemicals through biotechnology for various industries, aiming to make sustainability an easy economic choice.

Share medical imaging 99% faster and 100% digitally with the world's first digital films fulfillment platform.

Take control of your health. Reduce pain. Stress less. Improve focus. SHIFT.

Impulse Medical Technologies - A leading manufacturer and distributor of high-quality medical electrodes and diagnostic supplies. Parent company of The Electrode Store and TES Wholesale.

SeqOnce was co-founded in 2014 by Chris Angermayer and Joseph Dunham as a spinout from the University of Southern California, and has drawn investment from Wavemaker 360 Health and Mount Wilson Ventures.

BioSig Technologies (Nasdaq: BSGM), originally a medical-device company, pivoted into real-world-asset tokenization through a 2025 merger with Streamex Exchange, backed by mining financier Frank Giustra as a strategic advisor.

Abbott creates innovative medical devices and healthcare solutions for cardiovascular health, diabetes management, diagnostic testing, nutrition, chronic pain and more.

Controlled Delivery Systems is developing a medical device to treat venous insufficiency without thermal energy or a permanent implant.

Nano porous silicon particles for controlled release drug delivery for the treatment of ocular diseases such AMD and for application to oncology

Berman Medical is building the image-guided navigation layer for point-of-care procedures to make patient-specific 3D visualization and navigation accessible.

Azora Therapeutics, an LA biopharma founded in 2019 by Matt Davidson and Julie Saiki, was acquired by Adial Pharmaceuticals in 2026 for up to $64 million.

Developing Life-Changing Therapeutics For Our Pets Monoclonal antibodies (mAbs) for modern veterinary practices Developing Life-Changing Therapeutics For Our Pets Monoclonal... Read More

Caradon Therapeutics, Inc. develops novel disease-modifying peptide-based therapeutics for cardiometabolic diseases in humans and companion animals using proprietary enabling technology to create long-acting formulations.

GABA Therapeutics partnered with atai Life Sciences (co-founded by Florian Brand) in a Series A deal worth up to $15.5 million to develop a novel anxiety treatment; it was co-founded by Richard Farrell.

Explore Persperion for innovative sweat sensing technology and metabolic health monitoring at your fingertips.

Annie Health builds technology that helps hospices measure and improve the quality of care they deliver, and automatically communicates patient outcomes back to referral sources to drive differentiation and growth.

Timecap is a customizable habit tracker application designed to help users build healthy and productive habits.

LungLife AI is a diagnostic company focused on the early detection of lung cancer from a simple blood draw enhanced by artificial intelligence.

Our mission is to provide a compassionate, world-class customer experience to the families we serve.

Altolabs Inc. provides AI solutions for enterprises, designed for accountability, data residency, and full control over how intelligence is governed and deployed.

GT Optics provides custom optical design, engineering, and manufacturing for biomedical and photonics applications.

CeraRoot USA Inc. provides a ceramic implant system engineered for biological integration, offering various implant models, accessories, and services like custom prosthesis design and surgical guides.

AI phone agents that call, qualify, and route your leads in under a minute. Built-in CRM integrations for insurance, legal, financial, and medical businesses.

SWASTHAM TRUST supports needful patients by offering diverse medical services, including providing financial aid for cancer treatment and organizing free health check-up camps.

Ionava provides a financial preparedness system that rewards users for being healthy by offering a 'Vault' of reserved cash for major health events and a 'Wallet' for everyday wellness spending, with a portion of the subscription earning interest.

Celia Group, Inc., through Celia Health and CeliaRx, provides longevity-first telehealth services with personalized, proactive care, offering programs and pharmaceutical-grade peptides designed for health optimization.

Unlocking the microbiome for better skin health The Human Body Relies On The Microbiome For: Inflammation Control Infection Protection Wound Healing And More The Microbiome Cannot Be Ignored For over 100 years, "skincare" has often treated

PureSkinBoutique offers innovative skincare solutions, specifically the BYONIK® skincare collection and the SLIMYONIK® Body Duo, to enhance and deliver effective results supporting optimal long-term skin health and wellness.

Discover Trethera’s breakthrough therapy TRE-515 for autoimmune, oncology, and neuroinflammatory diseases. Learn about our science-driven innovation.

ClearPrice Networks, Inc. connects payers and providers directly, transparently, and electronically to eliminate rebilling vendor markups for DME, Orthotics & Prosthetics, Medical Supplies, and Home Care Services.

Struggling with your mental health? Our online counsellors meet with you through our video counselling platform, when and where it works best for you.

Healthy Crops is an international research project that aims to achieve significant yield increases for small-scale producers in Africa and Asia by providing disease-resistant rice varieties.

My Village Innovations (MVI Medical) is a women-led medical device company co-founded by Andrea "Annie" Munoz, PA-C, and Alfonso Munoz, focused on reimagining the vaginal speculum for gynecologic care.

Okogen, Inc. is a clinical stage ophthalmic pharmaceutical company focused on developing a comprehensive treatment for both bacterial and viral acute infectious conjunctivitis.

Operated as "The BXNG Club," a luxury boxing gym chain in San Diego; the company filed Chapter 11 bankruptcy in June 2024 and abruptly closed all its remaining locations.

Aisona Care Inc. offers Sona, an AI-powered care companion for Seniors that shares health signals securely with their care team.

Robin Capital backs ambitious founders at Angel to Series A. We invest in grit, software, and vision—supporting startups with capital, experience, and founder-first values.

Redbloom is the only gut healthy chili crisp bringing bold flavors to sensitive guts. Seed-Oil Free, Vegan, Low Fodmap, GF. We microencapsulate chili peppers in oleic acid from avocado oil, creating a layer of healthy fat to cushion the gut from spicy flare-ups - making the product truly gut-healthy.

Renova Therapeutics is focused on developing definitive treatments to restore health to people suffering from congestive heart failure and type 2 diabetes through transformational gene therapies.

Founded by MaryRose Reaston (co-founder/CSO) alongside CEO Brett Ottemeier; the Carlsbad-based company makes functional EMG diagnostic technology and has won an industry innovation award.

TrueRelief is an FDA-cleared, non-invasive medical device that delivers an electroceutical treatment that uses a patented combination of high frequency electrical current delivered dynamically by a skilled medical professional. The treatment itself is completely painless.

Carriero Foot and Ankle is a podiatric practice focused on treating foot and ankle conditions, led by Dr. Keenan Carriero and Dr. Zachary Kramer.

Unlocking New Indications for the in vivo CAR-T Modality

Seren Bio Corp. sells products categorized for weight loss, skin, hair and beauty, recovery, bacteriostatic water, and performance, energy & wellness.

Essential HR Services is a team of experienced, professional Human Resources (HR) Consultants specializing in Labor Law Compliance, Employee Relations, HR Administration, Organizational Development, Training, Health and Wellness Programs, and Payroll. Our goal is to deliver quality service, with the utmost integrity.

Serafin Labs is a San Diego cancer-therapeutics company founded by CEO Sural Ranamukhaarachchi (UC San Diego bioengineering PhD) and affiliated with UCSD's Fraley Lab; it is still operating in stealth mode.

Operait Health Inc. provides an end-to-end AI agent that aims to elevate patient experience, reduce operational costs, and improve outcomes for hospitals, health plans, and providers.