Medical Technology startups in Southern California

Celladon is a biotechnology company that focuses in the development of molecular therapies to treat heart failure.

Pear Sports is an Irvine; California-based company founded in 2010 by Bob Allison.

Cerulean Pharma; Inc is a company founded in 2006 by Ram Sasisekharan.

Combimatrix Molecular Diagnostics; Inc. is a company that is part of the Medical & Diagnostic Laboratories Industry.

SG Biofuels is a biotechnology company developing renewable fuels.

Crown Bioscience is a contract research organisation for drug discovery; best known for oncology models and also working in cardiovascular and metabolic disease; with sites across the United States; E

TigerText is a Santa Monica; California-based company.

Ignyta is a company that combines medicine and biotechnology for the treatment of cancer and autoimmune diseases.

A company developing therapeutics for veterinary medicine

A biopharmaceutical company that develops therapeutics to treat depressive disorders

A company focused on the development proteomics

A biotechnology company developing cancer therapeutics based on antibodies

Kareo is a medical billing services company providing a web-based medical practice management software.

A company that develops therapeutics for the treatment of cancer

PrescribeWellness is an Irvine; California-based company founded in 2010 by Al Babbington.

A life science devices company focused on the discovery and development of protein biomarkers as diagnostic tests

MD Insider is a Santa Monica; California-based company founded by Eric Wilson; David Norris and Jay Calvert.

Sotera Wireless is a medical device company engaged in the development of wireless vital signs monitoring devices.

Quality Systems is an Irvine; California-based company founded in 1992.

CombiMatrix is an Irvine; California-based healthcare company developing products and service for drug development; genetic analysis and diagnostics.

A company developing reagents for immunology; multicolor flow cytometry and biological system analysis

Femta Pharmaceuticals is a biotechnology company that develops protein therapeutics

A company developing pharmaceutical and diagnostic products to help physicians personalize patient care

Water Health International is a company founded in 2006.

A biopharmaceutical company developing small molecule therapeutics for respiratory and inflammatory disorders

TherOx is an Irvine; California-based company founded in 1995.

Genoptix is a Carlsbad; California-based medical diagnostics company offering next-generation sequencing for oncology founded in 1999 by Tina Nova.

Developing the next generation of oncology therapies for patients.

Mirador Therapeutics is focused on discovering and developing precision medicines for immune-mediated inflammatory and fibrotic diseases using its Mirador360™ engine, which harnesses biology, multi-modal data, AI, and advanced analytics.

Avidity Biosciences is a company driven by the mission to profoundly improve people's lives by revolutionizing a new class of targeted RNA therapeutics through its Antibody Oligonucleotide Conjugates (AOC™) platform.

Iambic has created a cutting-edge AI-driven platform to tackle the most challenging design problems in drug discovery and address unmet patient need.

Nalu Medical offers a neurostimulation system that provides a long-term solution for managing intractable chronic nerve pain.

Merck agreed to acquire the San Diego biotech for approximately $9.2 billion in November 2025.

Biolinq Inc. develops the Biolinq Shine™ sensor, which is a fully autonomous, needle-free glucose sensor that integrates glucose, activity, and sleep information.

Co-founded by Drew Weissman, the 2023 Nobel Prize winner in Physiology or Medicine for mRNA vaccine research, alongside CAR-T pioneer Carl June; the company was later acquired by AbbVie.

Rakuten Medical is developing the Alluminox® platform, an investigational platform based on photoimmunotherapy, to transform cancer treatments.

Founded by Ken Song and launched with over $370 million (later exceeding $500 million) from investors including Venrock Healthcare Capital Partners, RA Capital Management, and Fairmount.

Anchored by our protein-engineering expertise and our proprietary single-domain antibody platform, we’ve developed a unique pipeline of therapeutic candidates.

ADARx Pharmaceuticals, Inc. is a company that develops RNA medicines leveraging RNA science and proprietary targeted delivery platforms to silence the underlying cause of disease.

ABA therapy and comprehensive autism care for children, from diagnosis through developmental and medical therapy. Physician-led and in-network. Find a center near you.

TORL Biotherapeutics LLC is a biopharmaceutical company focused on the discovery, development, and commercialization of novel antibody-based therapies to improve and extend the lives of cancer patients.

Equip Health provides virtual eating disorder treatment through a 5-person care team that includes a therapist, medical provider, dietitian, family mentor, and peer mentor.

Lightship is a clinical trial site network that expands participant choice through in-clinic, hybrid, virtual, and mobile research models.

Pelage Pharmaceuticals, Inc. is developing regenerative medicines for hair loss, specifically PP405, a non-invasive, topically-applied small molecule solution that reactivates dormant hair follicles by targeting stem cells.

Endeavor BioMedicines is a clinical-stage biotechnology company developing transformational medicines for life-threatening diseases.

Renovaro revolutionizes cancer and neurology care through early detection, drug discovery, and personalized treatments. AI-powered precision medicine.

A Foresite Labs-incubated biotech backed by Foresite Capital, Qiming Venture Partners, and Samsara BioCapital that raised over $100M before being folded into Candid Therapeutics' $370M launch in 2024.

Autobahn aims to improve life health for people affected by CNS disorders by driving the regenerative power of the human body.

JenaValve Technology Inc. offers the Trilogy Transcatheter Heart Valve, which is an FDA-approved TAVR system specifically designed for aortic regurgitation, utilizing locator technology for alignment and secure anchoring.

Enlaza Therapeutics is pioneering the field of covalent biologics, developing a novel classes of protein therapeutics based on its proprietary War-Lock™ platform.

PatientFi, Inc. provides monthly payment plans to help patients break cost barriers for procedures in areas such as plastic surgery, medspa & dermatology, fertility, hair restoration, audiology, cosmetic dental, and vision.

TRC 2004 was co-founded by Third Rock Ventures and Two River, the same investor group behind Kite Pharma (sold to Gilead for roughly $11.9B), and later emerged publicly as Candid Therapeutics with a $370M capital raise.

Bright Peak Therapeutics is a company that uses its protein engineering capabilities to create multifunctional precision immunotherapies for the treatment of cancer.

Proactive health memberships combining Whole Body MRI, advanced blood biomarker testing, and ongoing clinical guidance—designed to help you track your health year over year.

Rebuilding healthcare with AI at the core

Bloom Nutrition provides health and wellness supplements for women, with high quality ingredients to support energy, gut health and hormone balance. Shop our greens, beauty and fitness supplements.

Part of the NantWorks ecosystem of biotech and health companies founded by billionaire physician-entrepreneur Patrick Soon-Shiong, who also owns the Los Angeles Times and invented the cancer drug Abraxane.

Gene therapy company that emerged from stealth in June 2023 with a $51M Series A co-led by Westlake Village BioPartners, developing AAV-based genetic medicines for muscle and heart disease.