Software & SaaS startups in Southern California

Nervana Systems was a San Diego-based company focused on the development of artificial intelligence and deep learning software. The company was acquired by Intel in 2016.

Company

SecureAuth is an Irvine; California-based provider of access control solutions for premises; cloud and web applications; and resources. Solutions include multi-factor authentication; single sign-on;

ExtendCredit is a web-based software platform enabling users to create and manage in-house customer financing plans.

BlueCava is an Irvine; California-based online advertising company using device identification services to reach across networks and technologies for advertising services.

Numecent is a cloud technology provider headquartered in Irvine; California.

SRCH2 is an Irvine; California-based company founded in 2010 by Chen Li.

OpenX runs a supply-side platform for programmatic advertising.

Kareo is a medical billing services company providing a web-based medical practice management software.

GoSave is a company that built an app that aims to teach children how to save money.

Pivotshare is an Irvine; California-based company founded in 2010.

Nirvanix is a San Diego-based company founded in 2007 by Edgard Capdevielle.

Guardtime's Black Lantern platform provides real-time cybersecurity and data-centric asset protection.

CloudBlue Technologies is a subsidiary of Ingram Micro that provides XaaS solutions and various platforms for company management.

Evolution; also known as Evolution Robotics; is a Pasadena; California-based software company founded in 2001.

Docstoc is a Santa Monica; California-based company founded in 2007.

Kofax is a robotic process automation company that digitizes complex and information-intensive workflows.

Brand of video codec products developed by divx; llc

Metropolis transforms the parking experience with a computer vision platform that enables checkout-free payment.

Avidity Biosciences is a company driven by the mission to profoundly improve people's lives by revolutionizing a new class of targeted RNA therapeutics through its Antibody Oligonucleotide Conjugates (AOC™) platform.

Iambic has created a cutting-edge AI-driven platform to tackle the most challenging design problems in drug discovery and address unmet patient need.

Rakuten Medical is developing the Alluminox® platform, an investigational platform based on photoimmunotherapy, to transform cancer treatments.

Anchored by our protein-engineering expertise and our proprietary single-domain antibody platform, we’ve developed a unique pipeline of therapeutic candidates.

ADARx Pharmaceuticals, Inc. is a company that develops RNA medicines leveraging RNA science and proprietary targeted delivery platforms to silence the underlying cause of disease.

Merkle Manufactory Inc. is a software company that contributes to the Farcaster protocol and works on clients.

Enlaza Therapeutics is pioneering the field of covalent biologics, developing a novel classes of protein therapeutics based on its proprietary War-Lock™ platform.

Advanced material solutions—from AI-driven design to agile U.S. manufacturing—for defense, aerospace, & high-performance applications

FDA-cleared dental AI that detects 37% more disease. Join 29,000+ dental practices using Pearl's dental AI software. Book a demo.

Kudos® is the recognition and rewards platform designed to fit your unique workplace culture.

HiveWatch provides a platform that unifies physical security systems into one AI-powered command center to help security teams prioritize incidents and automate responses.

Tide Rock is a growth platform for B2B companies that acquires founder-run businesses using an unlevered buyout model to grow their legacy.

Virtualitics is an AI solutions company that transforms data into impactful action with AI readiness applications for defense, government, and enterprise.

Epsilyte manufactures expandable polystyrene EPS materials for insulation, protective packaging, cold chain, foodservice, and molded applications.

Affinity Biosensors’ LifeScale platform delivers rapid, high-throughput phenotypic antimicrobial susceptibility testing in under four hours, empowering clinical labs to make timely antibiotic decisions and combat drug-resistant infections.

Salted Inc. is a platform that builds national, digital-first restaurant brands with clean, craveable food designed for a new generation.

Price with precision. Negotiate with confidence. Turquoise is the platform 300+ healthcare organizations use to make sense of rates, contracts, and compliance.

Enhance, extend or replace your legacy GTM software with affordable enterprise-grade AI-native trade and tariff management software from KYG Trade.

Mapped turns any building's systems, sensors, and devices into a structured, real-time world model — the data foundation AI agents and applications need to understand and act on the physical world.

Mesa Residential partners with market-leading property managers to grow for decades as a multigenerational platform with over 50 years of history building exceptional growth companies.

AI-powered risk adjustment software designed to increase the profitability of Medicare risk contracts.

The 1st warehouse-native platform for experimentation, feature flags, and product analytics. Open source and fully transparent. Trusted by 3,000+ companies.

Lumati is a global holistic wellness optimization platform redefining longevity through science, technology, and personalized care — supporting cellular health, promoting recovery, and sustaining vitality.

FinOps governance for platform teams. Prevent cloud waste and budget overruns before every deploy.

Sift is the unified observability platform for mission-critical hardware—ingest, store, and analyze telemetry at scale across aerospace, defense, and robotics.

Unlock quantum power with BlueQubit's quantum computing software! Seamlessly access and utilize quantum computers for groundbreaking advancements.

The integrated platform for the electromagnetic spectrum. One platform for RF design, production, and network operations.

Nuon Inc. provides continuous delivery solutions that enable software vendors to deploy applications into their customers' clouds, supporting use cases like data sovereignty and security.

Mixed-Signal Devices Inc. delivers multi-gigahertz digital timing solutions with ultra-low jitter, stability, and programmability for AI infrastructure, 5G networks, and high-performance automotive platforms.

TadHealth is the leading school-based EHR platform designed for K‑12 schools, empowering mental health professionals with intuitive tools to manage care, streamline operations, and improve student outcomes.

An integrated communications platform using cloud-hosted phone, chat, contact center and analytics to meet the challenges of today’s business.

Syndex Bio introduces mcPCR, a novel and proprietary platform technology that preserves DNA methylation during DNA amplification, enabling simpler, faster, and more sensitive analysis of methylated DNA.

AI-powered optimization platform that uses domain-trained intelligent agents built for operations teams.

Soapbox provides a platform that centralizes, simplifies, and orchestrates order management, inventory management, and shipping management across the entire supply chain.

Valora Therapeutics is developing AbLec™ multispecific antibodies and T-Lec™ T cell engagers — antibody-engineering platforms that decoy the glyco-immune checkpoint to create best-in-class therapeutics for cancer and autoimmune disease.

Develo Inc. provides AI-native pediatric software built as an operating system for charting, billing, practice management, and family experience for independent pediatric practices.

Picogrid delivers integrated systems for modern missions, connecting sensors, platforms, and operators across land, sea, air, and space.

The AI control plane for discovering, securing, and governing AI agents, MCP servers, and AI applications across your enterprise.

Leeta Materials, Inc. manufactures ceramic powders and sintered components designed to meet precise industrial requirements for applications in various industries.

We're an ambitious startup developing a groundbreaking new UGC gaming platform.

Transform your productivity, efficiency & scalability through the MES manufacturing software from First Resonance!