The city courted the U.S. Navy in the early 1900s, and Naval Base San Diego opened in 1922, planting the military and engineering roots the region still runs on. UC San Diego professor Irwin Jacobs founded Linkabit in 1968 and later Qualcomm in 1985, inventing wireless technology at the heart of 3G and 4G. A few miles away, fellow UCSD professor Ivor Royston launched Hybritech in 1978, the region's first biotech company. San Diego is now one of the world's top biotech clusters.

Shield AI is a defense-tech company building the world's best AI pilots and next-generation aircraft.

Firestorm Labs - Democratize the fight with radically-affordable, mission-adaptable power for air, land, and sea.
Electrochemical Additive Manufacturing Mass Production of Next Generation Components High-Resolution Metal 3D Printing at Scale Electrochemical Additive Manufacturing (ECAM) is... Read More

Gallant offers ready-to-use stem cell therapies that help pets heal from within, restoring vitality and supporting longer, healthier lives.

Brain Corp is an autonomous technology company powering the most proven robots and AI, helping organizations create more productive and intelligent operations.
Founded by Ryne O'Donnell in 2014, who self-funded the company; he briefly sold his majority stake and left in 2017 before returning as chairman.

Price with precision. Negotiate with confidence. Turquoise is the platform 300+ healthcare organizations use to make sense of rates, contracts, and compliance.
Operates as Seasats; CEO and co-founder Mike Flanigan launched the San Diego autonomous-vessel maker in 2020, and it closed a $20 million Series A backed by Philip Bilden.
The Encinitas-based clinical-stage biotech was acquired by Eli Lilly for $1.2 billion in cash, after IPOing on Nasdaq (VTYX) in 2021.

Avaamme mahdollisuudet ja takaamme sinulle paremman kasvun: Arvo Partners, täyden palvelun digitaalinen markkinointitoimisto ja tuleva strateginen kumppanisi.

NIS, a US based CRO, provides cryo-EM services to accelerate drug discovery, with structural biology, nanoparticle characterization, and GMP compliant imaging.

FinOps governance for platform teams. Prevent cloud waste and budget overruns before every deploy.

An integrated communications platform using cloud-hosted phone, chat, contact center and analytics to meet the challenges of today’s business.
JS-WR JV, Inc. does business as Willie's Remedy+, the CBD/THC beverage and wellness product line created by musician Willie Nelson.

Founder and CEO Gerald Proehl previously led Santarus Inc. through its $2.6 billion sale to Salix Pharmaceuticals.
Modular Medical was founded by Paul DiPerna, who also founded Tandem Diabetes Care in 2005 and invented its t:slim insulin pump; the company is now led by CEO Jeb Besser.

BlueNalu, Inc. develops cell-cultivated seafood, beginning with bluefin tuna toro—crafted with care and produced without fishing.
Founded by Dr. S. Eric Ryan, a former Volcano Corporation VP, Provisio Medical develops intravascular ultrasound smart-catheter technology and has raised tens of millions in venture funding, including backing tied to MedTech Innovator.
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A piezoacoustic platform technology that makes the world’s batteries last longer, charge faster, and be safer.
Get instant real-time visibility with EdgeX. Wire-free RTLS, asset tracking, and environmental monitoring. Fast ROI, no IT burden, deployed in hours.

Vimcal is the world’s fastest calendar, beautifully designed for people who have too many meetings. Drag to share availabilities, schedule across time zones, and see all your Outlook and Google calendars in one view.
Search engines and social networks are not designed for due diligence. Ferret’s unparalleled AI platform combined with world class information provides you with exclusive relationship intelligence that can help you avoid high-risk individuals and spot promising opportunities.

Technology purpose-built for libraries, archives, and museums for improving Access, Searching, Resource Sharing (interlibrary loan) & Digital Preservation.

Measurabl offers comprehensive ESG solutions, empowering businesses with data-driven insights for sustainability & compliance. Learn More
Non-toxic deodorants are only good when they're effective. Our plant & mineral based formulas work on all skin types to keep you smelling fresh all day. Aluminum Free Deodorant | Non-Toxic, Paraben & Cruelty Free Free shipping on orders over $25 | Subscribe and save 15%

Serenity is a unified EHS platform built on ServiceNow for incident management, audits, risk assessments, compliance, and cyber risk — with AI-powered safety insights.
Co-founded by James Brailean, previously of Snaptrack (the GPS technology company Qualcomm acquired for about $1 billion), alongside Thilo Hoelscher, inventor of the company's SONAS platform technology.
Also known as FuturHealth, this San Diego weight-loss company was co-founded and is led by CEO Luke Mahoney.

As leaders in cathode innovation, we develop materials that drive clean energy solutions. Click here to explore our pioneering work in battery technology.
Co-founded by physicists Dr. Massimiliano Di Ventra and Dr. Fabio Traversa alongside serial entrepreneur John Beane, previously a founder of ecoATM; investors include DARPA and Revolution's Rise of the Rest Seed Fund.

SkySafe’s advanced drone detection system and airspace intelligence platform enables organizations to identify, track, analyze, and act on unauthorized drone activity.
Also known as Elevate Dynamics; co-founder Daniel Magy previously founded Citadel Defense Company, a counter-drone defense firm that was later acquired by Blue Halo.

GTR helps home service companies grow with referral software, branded apps, and automated rewards. Turn happy customers into your best lead source.

Aervivo enables our Partners to provide community wide Gigabit managed WiFi, delighting the communities they serve and generating an outstanding 100%+ IRR, quickly.

Crop Diagnostix uses plant RNA to detect asymptomatic crop stress before symptoms appear. Asymptomatic Agronomy for partners, retailers, and input providers.

Soleic technology is the world's first fully biodegradable, high performance polyurethane material. Plant-based. Zero microplastics.

Self Inspection uses AI trained on 20M+ images to automate vehicle damage detection, condition reports, and CR scoring — built for dealers, fleets, rentals, and lenders.
Founded in 2014 by Patrick Henry, Farooq Anjum, and Jeff Campbell, the agtech soil-sensor company was acquired by Goanna Ag in August 2025.
Growthsayer was founded by Phillip Geltman, a San Diego-based supply chain specialist who originally built the platform to optimize cannabis industry supply chains before expanding into broader retail demand planning.
Hauler Hero is a waste management software solution that helps waste haulers improve their operations, increase efficiency, and reduce costs.

Streamline your functional health business with Biocanic to get better better scale and outcomes for you and your clients.
RCPS LLC does business as "Bulkhead," an energy drink brand based in Chula Vista, California.
Operating as Assumable.io, it was co-founded by Ryan Carrillo and Louis Ortiz and drew national coverage (including the New York Times) for its marketplace matching buyers with homes carrying low-rate assumable mortgages.
TPT Global Tech is a technology holding company with an emphasis on Media Content, Medical Technology and Telecommunications.

Recruitment CRM for full-time, seasonal, and contract talent. Outreach automation keeps relationships warm and makes rediscovery easy. Works with your ATS.
San Diego cancer-drug-discovery company co-founded in 2020 by Pilgrim Jackson (13 years at Celgene) and Afshin Mahmoudi; backers include CONNECT San Diego.
Founded by Austen Sybert in 2020 as an acquisition vehicle that bought and now operates Atlas Crane Service (a crane-services roll-up), rather than a from-scratch startup.
For the ones who believe fun comes in all forms, there’s Improv Cocktails.Our full-flavored, premium non-alcoholic cocktails taste like the real deal, but without the booze. They’re ready to enjoy if you’re going dry, and ready to spike if you’re not.
Led by CEO Jim Saxon, the Southern California holding company partnered with Spain's Mora-Figueroa Domecq, S.L. for tequila product management.
Terafiber was founded by Jim Hanley, a San Diego fiber-infrastructure entrepreneur who had previously founded Netly Fiber, another citywide fiber-network builder, before starting Terafiber in 2023.

Mobile fundraising platform for nonprofits with compliant text messaging, Text-to-Give, and donor engagement. Trusted by 1,000+ organizations.
GenseeAI, an AI agent infrastructure startup, was co-founded by UC San Diego professor Dr. Yiying Zhang and former Google tech lead Dr. Shengqi Zhu, and is backed by Two Small Fish Ventures.

SmartProperty's Living Reserve Study gives HOA and condo boards real-time reserve fund tracking, capital planning, component inventory, and project management — replacing outdated static reserve studies with a dynamic, always-current platform.

Create engaging, interactive presentations effortlessly with Tiled. Enhance your storytelling and captivate your audience with dynamic, customizable content.
Chefs Life was created in early 2021 by celebrity chef Brian Malarkey (a Top Chef alum and San Diego restaurateur).
San Diego-based AI-powered polling and community-forum platform for digital publishers, founded by Scott Kaplan, a longtime ESPN 710 LA sports radio host.

Discover the world's most extraordinary collection of perspective-changing rooms, mind-bending installations, and optical illusions.
Blending a Japanese style whisky that harmonizes Japanese nature and artisanship
San Diego-based SuperMem was founded by Yu Lu and has received funding including from the National Science Foundation and Techlink Ventures.
Founded by CEO Sucheta Godbole Deshpande, who in 2025/2026 appointed Theresa M. Brady to the company's board of directors as it builds out its AI-driven lifestyle health platform.

We believe that everyone - including those with sensitivities and allergies - should be able to enjoy fragrance. Our non-toxic fragrances are formulated to be free of all 82 EU fragrance allergens and top 9 food allergens, on top of being free from hormone disruptors and carcinogens.
M&R Technology, Inc. does business as The Infinity Shield and holds a U.S. patent (invented by Magid Fazel and colleagues) for garage-door safety sensors designed to protect pets and family members from accidental door strikes.
Site Bionics unlocks AI for physical retail, enhancing loss prevention, optimizing store operations, and improving customer experience.
Wallabi is your AI transformation partner. A strategy and implementation firm specializing in AI and data, built by leaders from Tableau, Salesforce, and Google.

Financial Freedom with Bitcoin. The digital assets partner for your business. OTC, Swaps, and Enterprise-Grade Solutions
RPGMatch, a Los Angeles-based tabletop-gaming matchmaking startup, acquired the long-running gaming community site RPGnet in a 2024 merger, with RPGMatch owner Joaquin Lippincott becoming CEO of the combined company.

AI-Enabled Quality and Regulatory Workflows
According to its founder's LinkedIn profile, Greenview Labs is a golf technology startup founded by Harrison Fitz.
Founded by Wharton MBA Paul Dohrenwend; its premium sake made its retail debut at a Costco in San Diego.

Craitor is a San Diego defense startup founded in 2019 by UC San Diego alum Eric Shnell (CEO) and Meher Akhil Birlangi; per Forbes, it has secured $3.3 million in U.S. government contracts.

Influsence's Chief Advisor is Gil Eyal, founder of HYPR, the influencer-marketing platform he built and later sold (to Julius/JW) in 2020.


Faster processors for solving NP-complete problems


LinkedIn content consultancy and scheduling platform for busy founders


Sourcify helps brands manufacture products in Asia.